NAFDL is defined as an ectopic lipid accumulation in hepatocytes. There is a strong correlation between obese patients with type 2 diabetes and NAFLD; in fact, over 90% of obese, type 2 diabetic patients have NAFLD. Diet-induced inflammation has been hypothesized as crucial for the development of obesity, NAFLD and T2D. Apolipoprotein J (or clusterin), a protein expressed by the liver, promotes anti-inflammatory and antioxidant actions. It serves as a chaperone for antioxidant enzymes, including paraoxonase-1 (PON-1). We aim to determine the roles of these proteins in counteracting the pro-oxidant and pro-inflammatory burden of high-fructose and high-fat diets.