Publications

  1. M Paula Macedo, Rogério Ribeiro, João F Raposo. 5-Fructosamine, 1,5-Anhydroglucytol, Glycated Albumin-tools for detecting glycemic disorders. Endocrine Reviews (2019, in press) (IF: 15, 745; Q1).
  2. Gnaiger E, Aasander Frostner E, Abdul Karim N, Abumrad NA, Acuna-Castroviejo D, Adiele RC, Macedo MP et al. Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v4. 2019.
  3. João F. Raposo, M Paula Macedo, Rogério Ribeiro. Controversies and Current Approaches in the Diagnosis of Prediabetes and Diabetes: HbA1c, fructosamine, and glycated albumin in the detection of dysglycemic conditions. Curr Diabetes Rev. 2016;12(1):14-9. PMID: 26126638 (IF: 3.56, Q1).
  4. Maria Paula Macedo, Inês S. Lima, Joana M. Gaspar, Rita S. Patarrão, Ricardo A Afonso and Rogério T Ribeiro. Risk of postprandial insulin resistance: the liver/vagus rapport. Rev Endocr Metab Disord. 2014 Mar;15(1):67-77. (IF: 4.96; Q1).
  5. João Silva, Cátia Marques, Fátima Martins, Ivan Viegas, Ludgero Tavares, Maria Paula Macedo*, John G. Jones*. Determining Contributions of Exogenous Glucose and Fructose to de novo Fatty Acid and Glycerol Synthesis in Liver and Adipose Tissue. Metabolic Engineering (2019, in press) (IF 8.494, Q1).
  6. Meneses MJ, Borges DO, Dias TR, Martins FO, Oliveira PF, Macedo MP*, Alves MG*. Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality. Mol Cell Endocrinol. 2019 Apr 15;486:11-17. doi: 10.1016/j.mce.2019.02.011. (IF: 3.693, Q1).
  7. Ana Marta Matos, Alice Martins, Teresa Man, David Evans, Magnus Walter, Maria Conceição Oliveira, Oscar Lopez-López, José M. Fernandez-Bolaños, Philipp Dätwyler, Beat Ernst, Maria Paula Macedo, Marialessandra Contino, Nicola Colabufo, Amelia P. Rauter. Design and synthesis of CNS-targeted flavones and analogues with neuroprotective potential against H2O2- and Abeta1-42-induced toxicity in SH-SY5Y human neuroblastoma cells. Pharmaceutics. June 2019 (in press). (IF: 4.773, Q1)
  8. Diego O. Borges, Maria João Meneses, Tânia R. Dias, Fátima O. Martins, Pedro Oliveira, Marco G Alves, M. Paula Macedo. Data on metabolic profile of insulin-degrading enzyme knockout mice. Data in Brief, Volume 25, August 2019, Article 104023.
  9. Gonçalves-Dias C, Morello J, Correia MJ, Coelho NR, Antunes AMM, Macedo MP, Monteiro EC, Soto K, Pereira SA. Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease. Nephron. 2019 Jan 9:1-7. doi: 10.1159/000494390. (IF: 2.085, Q1).
  10. Catarina Dias, Ana M. Matos, Maria T. Blásquez-Sanchez, Patrícia Calado, Alice Martins, Philipp Dätwyler, Beat Ernst, M. Paula Macedo, Nicola Colabufo, Amélia P. Rauter, 2-Deoxyglycosylation towards more effective and bioavailable neuroprotective molecules inspired by nature. Pure and Applied Chemistry. DOI: https://doi.org/10.1515/pac-2019-0303, 2019. (IF: 5.294, Q1).
  11. Hu Huang, Seung-Hwan Lee, Inês Sousa-Lima, Sang Soo Kim, Won Min Hwang, Yossi Dagon, Min-Cheol Kang, Ji A Seo, Munehiko Shibata, Hyunsoo Cho, Getachew Debas Belew, Jinhyuk Bhin, Bhavna N. Desai, Min Jeong Ryu, Minho Shong, Peixin Li, Hua Meng, Byung-Hong Chung, Daehee Hwang, Min-Seon Kim, KS Park, M Paula Macedo, Morris F. White, John Jones, Young-Bum Kim Rho-kinase is a novel regulator of hepatic lipogenesis during overnutrition. J Clin Invest. 2018 Dec 3;128(12):5335-5350. doi: 10.1172/JCI63562. (IF: 13.251, Q1).
  12. Nádia Duarte, Inês Coelho, Denys Holovanchuk, Joana Inês Almeida, Carlos Penha-Gonçalves and Maria Paula Macedo. Dipeptidyl Peptidase-4 (CD26/DPP-4) is a Pro-recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells. Hepatology Communications. 2018 Sep 7;2(9):1080-1094. doi: 10.1002/hep4.1225. eCollection 2018 Sep. (IF: not yet with IF belong to the Hepatology Journal which has an IF of 14.079).
  13. Ana Marta de Matos, Maria Paula Macedo, Amélia Rauter. Briging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential. Med Res Rev. 2017-04-19. (IF: 8.290, Q1).
  14. Inês Sousa-Lima; Shin-Young Park; Michelle Chung; M Paula Macedo; Young-Bum Kim Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice. Metabolism Clinical and Experimental. October 2016. Volume 65, Issue 10, Pages 1508–1521. (IF: 5.963, Q1).
  15. Martins M, Boavida JM, Raposo JF, Froes F, Nunes B, Ribeiro RT, Macedo MP, Penha-Gonçalves C. Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients. BMJ Open Diabetes Res Care ;4(1):e000181. doi: 10.1136/bmjdrc-2015-000181. eCollection 2016. (IF: 5.067, Q1).
  16. Coelho M, Mendes VM, Lima IS, Martins FO, Fernandes AB, Macedo MP, Jones JG, Manadas B. Direct analysis of [6,6-(2)H2]glucose and [U-(13)C6]glucose dry blood spot enrichments by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:242-8. doi: 10.1016/j.jchromb.2016.04.027 (IF: 2.813, Q1).
  17. Gaspar JM, Baptista FI, Macedo MP, Ambrósio AF. Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline. ACS Chem Neurosci. 2016 Feb 17;7(2):131-42. doi: 10.1021/acschemneuro.5b00240. PMID: 26667832. (IF: 4.348, Q1).
  18. Martins FO, Delgado TC, Viegas J, Gaspar JM, Scott DK, O'Doherty RM, Macedo MP*, Jones JG*. Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia. Br J Pharmacol. 2016 Jan;173(2):267-78. doi: 10.1111/bph.13362. PMID: 26447327. (IF: 6.810, Q1).
  19. Domenico Tricò, Simona Baldi, Alberto Tulipani, Silvia Frascerra, Maria Paula Macedo, Andrea Mari, Ele Ferrannini, Andrea Natali Mechanisms through which a small protein and lipid preload improves glucose tolerance in subjects with normal or impaired glucose homeostasis. Diabetologia. 2015 Nov;58(11):2503-12. doi: 10.1007/s00125-015-3710-9. PMID: 26224101. (IF: 6.206, Q1).
  20. Ricardo Afonso, Joana Gaspar, Iva Lamarão, W. Wayne Lautt, M. Paula Macedo. Postprandial insulin action relies on meal composition and hepatic parasympathetics: dependency on glucose and amino acids. J Nutr Biochem. 2016 Jan; 27:70-8. doi:10.1016/j.jnutbio.2015.08.023. PMID: 26410344. (IF: 4.668, Q1).
  21. João F. Raposo, M Paula Macedo, Rogério Ribeiro. Controversies and Current Approaches in the Diagnosis of Prediabetes and Diabetes: HbA1c, fructosamine, and glycated albumin in the detection of dysglycemic conditions. Curr Diabetes Rev. 2016; 12(1):14-9. Review. PMID: 26126638. (IF: 3.568, Q1).
  22. Fátima Martins, Teresa Delgado, Joana Viegas, Joana Gaspar, Robert O'Doherty, Donald Scott, M. Paula Macedo*, John Jones*. Mechanisms by which Thiazolidinediones Protect Against Sucrose-induced Fatty liver and Hyperinsulinemia. Br J Pharmacol. 2016 Jan;173(2):267-78. doi: 10.1111/bph.13362. PMID: 26447327. (IF: 6.810, Q1).
  23. Nadia Duarte, Inês Coelho, Rita Patarrão, Joana Almeida, C. Penha-Gonçalves and Maria Paula Macedo. How inflammation impinges on NAFLD: a role for Kupffer cells. Biomed Res Int. 2015:984578. doi: 10.1155/2015/984578. Review. PMID: 26090470. (IF: 2.583, Q1).
  24. Rita S. Patarrão, W. Wayne Lautt, M. Paula Macedo. Acute glucagon induces postprandial peripheral insulin resistance. PLoS One. 2015 May 11;10(5):e0127221. doi: 10.1371/journal.pone.0127221. PMID: 25961284. (IF: 3.234, Q1).
  25. Jesus AR, Dias C, Matos AM, de Almeida RF, Viana AS, Marcelo F, Ribeiro RT, Macedo MP, Airoldi C, Nicotra F, Martins A, Cabrita EJ, Jiménez-Barbero J, Rauter AP. Exploiting the therapeutic potential of 8-β-d-glucopyranosylgenistein: synthesis, antidiabetic activity, and molecular interaction with islet amyloid polypeptide and amyloid β-peptide (1-42). 2014. J Med Chem. Nov 26;57(22):9463-72. (IF: 6.054, Q1).
  26. Macedo MP*. Bridges in translational medicine: a case for metabolism, inflammation, and nutrition. 2014. C. J Physiol Pharmacol. Aug;92(8):iii. (IF: 2.210, Q2).
  27. Macedo MP*, Lima IS, Gaspar JM, Afonso RA, Patarrão RS, Kim YB, Ribeiro RT. Risk of postprandial insulin resistance: the liver/vagus rapport. 2014. Rev Endocr Metab Disord. Mar;15(1):67-77. (IF: 4.963, Q1).
  28. Trovoada Mde J, Martins M, Ben Mansour R, Sambo Mdo R, Fernandes AB, Antunes Gonçalves L, Borja A, Moya R, Almeida P, Costa J, Marques I, Macedo MP, Coutinho A, Narum DL, Penha-Gonçalves C. NOS2 variants reveal a dual genetic control of nitric oxide levels, susceptibility to Plasmodium infection, and cerebral malaria. 2014. Infect Immun. Mar;82(3):1287-95. (IF: 4.156, Q1).
  29. Pinto P, Bárbara C, Montserrat JM, Patarrão RS, Guarino MP, Carmo MM, Macedo MP, Martinho C, Dias R, Gomes MJ. Effects of CPAP on nitrate and norepinephrine levels in severe and mild-moderate sleep apnea. 2013. BMC Pulm Med. Mar 13;13:13. (IF: 2.760, Q1).
  30. Teresa C. Delgado, Fátima Martins, Filipa Carvalho, Ana Gonçalves, Donald K. Scott, Robert O’Doherty, M. Paula Macedo and John G. Jones 2H-enrichment distribution of hepatic glycogen from 2H2O reveals the contribution of dietary fructose to glycogen synthesis. 2013. Am J Physiol. 304: E000–E000. (IF: 4.125, Q1).
  31. Martins FO, Rito J, Jarak I, Viegas I, Pardal MA, Macedo MP, Jones JG. Disposition of [U-2H7]glucose into hepatic glycogen in rat and in seabass. 2013. Comp Biochem Physiol A Mol Integr Physiol. Oct;166(2):316-22. (IF: 2.240, Q2).
  32. Natali A, Ribeiro R, Baldi S, Tulipani A, Rossi M, Venturi E, Mari A, Macedo MP, Ferrannini E. Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion. 2013. Diabetologia. May;56(5):1183-91. (IF: 6.206, Q1).
  33. Ricardo A. Afonso, Ana B. Fernandes, Celina Santos, Dario Ligeiro, Rogerio T. Ribeiro, Rita S. Patarrao, Ines S. Lima, Paula A. Videira, Jorge Caldeira, M. Paula Macedo. Postprandial insulin resistance in zucker diabetic fatty rats is associated with parasympathetic-no axis deficiencies. 2012. J. Neuroendocrinol. Oct;24(10):1346-55. (IF: 3.331, Q1).
  34. Patarrão RS, Lautt WW, Afonso RA, Ribeiro RT, Fernandes AB, Boavida JM, Macedo MP. Postprandial but not fasting insulin resistance is an early identifier of dysmetabolism in overweight subjects. 2012. Can. J Physiol Pharmacol. 90(7):923-31. (IF: 2.210, Q2).
  35. Fernandes AB, Guarino MP, Macedo MP. Understanding the in-vivo relevance of S-nitrosothiols in insulin action. 2012. Can J Physiol Pharmacol. Jul;90(7):887-9. (IF: 2.210, Q2).
  36. Lautt WW, Schafer J, Macedo MP and Legare DJ. Bethanechol and N-acetylcysteine mimic feeding signals and reverse insulin resistance in fasted and sucrose-induced diabetic rats. Can J Physiol Pharmacol. 89, 135-142, 2011. (IF: 2.210, Q2).
  37. Ana B. Fernandes, Rita S. Patarrão, Paula A. Videira and M. Paula Macedo. Understanding postprandial glucose clearance by peripheral tissues: the role of the hepatic parasympathetic system. 2011. J Neuroendocrinol. Dec;23(12):1288-95. (IF: 4.650, Q1).
  38. Afonso RA, Lautt WW, Schafer J, Legare DJ, Oliveira, AG and Macedo, MP. High-fat diet results in post-prandial insulin resistance that involves parasympathetic dysfunction. Br J Nutr. Nov;104(10):1450-9, 2010. (IF: 3.657, Q1).
  39. Lautt WW, Ming Z, Macedo MP, Legare DJ. HISS-dependent insulin resistance (HDIR) in aged rats is associated with adiposity, progresses to syndrome X, and is attenuated by a unique antioxidant cocktail. Exp Gerontol. Aug;43(8):790-800, 2008. (IF: 3.804, Q1).
  40. Rita S Patarrão, W Wayne Lautt, Maria Guarino, Ricardo A. Afonso, Rogério T. Ribeiro, Ana B. Fernandes, José M. Boavida and M. Paula Macedo. A New Technique to Assess Insulin Sensitivity in Humans: The Rapid Insulin Sensitivity Test (RIST). Proc. West. Pharmacol. Soc. 50: 105-109, 2007. (IF:1.739 , Q3).
  41. Celina Santos, Ricardo A Afonso, Maria P Guarino, Rita S Patarrao, Ana B Fernandes, Maria P Macedo, Jorge Caldeira. In vitro Nitrosation of insulin A and B-chains. EJMS 12: 331-338, 2006. (IF: 1.435, Q2).
  42. Rogério T. Ribeiro, Ricardo A. Afonso, Maria P. Guarino, M. Paula Macedo. Loss of Postprandial Insulin Sensitization During Aging. J. Gerontol. A. Biol. Sci. Med. Sci. 63: 560-565, 2008. (IF: 5.95, Q1).
  43. Rita S. Patarrão, W.Wayne Lautt, Maria P. Guarino, Ricardo A. Afonso, Rogério T. Ribeiro, Ana B. Fernandes, J. Manuel Boavida e M. Paula Macedo. Meal-induced insulin sensitization and its parasympathetic regulation in humans. Can J Physiol Pharmacol. Dec;86:880-888. 2008. (IF: 2.210, Q2).
  44. Ricardo A. Afonso, W. Wayne Lautt, Rogério T. Ribeiro, Dallas Legare, M. Paula Macedo. Insulin resistance in two animal models of obesity: a comparison between the high-fat diet-fed and the Zucker rats. Proc. West. Pharmacol. Soc. 50: 110-114, 2007. (IF:1.739, Q3).
  45. Afonso RA, Ribeiro RT, Fernandes AB, Patarrão RS, Macedo MP. Hepatic-dependent and -independent insulin actions are impaired in the obese Zucker rat model. Obesity, Silver Spring. Feb;15(2):314-21, 2007. (IF: 4.042, Q1).
  46. Rogério T. Ribeiro, Ricardo A. Afonso and M. Paula Macedo. Hepatic parasympaphetic role in insulin resistance on an animal model of hypertension. Metabolism 56: 227-233, 2007. (IF: 5.963, Q1).
  47. Maria P. Guarino, and M. Paula Macedo. Coadministration of glutathione and nitric oxide enhances insulin sensitivity in wistar rats. Br. J. of Pharmacol. 147(8):959-965, 2006. (IF: 6.810, Q1).
  48. Parissa Sadri, Maria A.G. Reid, Ricardo A. Afonso, M. Paula Macedo, Joshua Schafer, Dallas J. Legare, W. Wayne Lautt Meal-induced insulin sensitization quantified in conscious and anesthetized rat models comparing liquid mixed meal with glucose and sucrose. Br. J. Nutr. 95: 288-295, 2006. (IF: 3.657, Q1).
  49. Ricardo A. Afonso, Rita S Patarrão, M. Paula Macedo, M. Mota Carmo. Carvedilol Action is Dependent on Endogenous Production of Nitric Oxide. Am. J. of Hypertension April 19:419-425; 2006. (IF: 3.541, Q1).
  50. Rogério T. Ribeiro, W.W. Lautt, D.J. Legare and M. Paula Macedo. Insulin resistance induced by sucrose-feeding is due to an impairment of the Hepatic Parasympathetic Nerves. Diabetologia 48: 976-983; 2005. (IF: 6.206, Q1).
  51. WW Lautt, MP Macedo, MS d´Almeida, DJ Legare, MAG Reid, MP Guarino. Pharmaceutical reversal of meal-induced insulin resistance. Proc. West. Pharmacol. Soc. 47: 30-32, 2004. (IF:1.739, Q3).
  52. Maria P Guarino, NC Correia, WW Lautt and M Paula Macedo. The Ach/ NO/cGMP pathway in the liver and its role in insulin sensitivity. Am. J. Physiol. Gastrointest. Liver Physiol. 287: G527-G532, 2004. (IF: 3.729, Q1).
  53. Ricardo Afonso, Rogério T. Ribeiro and Maria Paula Macedo. HISS-Dependent Insulin Resistance in Spontaneously Hypertensive Rats Results from Impaired Hepatic Nitric Oxide Action and can be Reversed by SIN-1. Proc. West. Pharmacol. Soc. 47, 2004. (IF:1.739, Q3).
  54. Maria Guarino, Ricardo Afonso, Nuno Raimundo, JF Raposo and M Paula Macedo. Hepatic gluthatione and nitric oxide are critical for hepatic insulin-sensitizing substance action. Am J Physiol Gastrointest Liver Physiol Jul;284(4):G588-594, 2003. (IF: 3.729, Q1).
  55. NC Correia, MP Guarino, JF Raposo and M Paula Macedo. Hepatic guanylyl cyclase inhibition induces HISS-dependent insulin resistance. Proc W. P.S. 45:57-58, 2002. (IF:1.739, Q3).
  56. RT Ribeiro, RA Afonso and MP Macedo. The action of hepatic insulin sensitizing substzance: gender compation in wistar rats. Proc W. P.S. 45:55-56, 2002. (IF:1.739, Q3).
  57. RT Ribeiro, F Duarte-Ramos and MP Macedo. The action of hepatic insulin sensitizing substance is decreased in rats on a high-sucrose diet. Proc. West Pharmacol. Soc. 44: 31-32, 2001. (IF:1.739, Q3).
  58. RT Ribeiro, F Duarte-Ramos and MP Macedo. The fatty zucker rat fa/fa shows a dysfunction of the HISS-dependent and - independent 9components of insulin action. Proc. West Pharmacol. Soc. 44:29-30, 2001. (IF: 1.739, Q3).
  59. RT Ribeiro, F Duarte-Ramos and MP Macedo. Effect of the hepatic insulin sensitizing substance (HISS) action in the spontaneously hypertensive rats. Proc. West Pharmacol. Soc. 44:27-28, 2001. (IF: 1.739, Q3).
  60. Maria P Guarino, NC Correia, JF Raposo and M Paula Macedo. Nitric oxide synthase inhibition decreases hepatic insulin sensitizing substance output which is reversed by SIN-1 but not by nitroprusside. Proc. West Pharmacol. Soc. 44:25-6, 2001. (IF:1.739, Q3).
  61. Rita Patarrão, M Paula Macedo, M Mota Carmo. Hepatic Metabolic Effects of Norepinephrine are potentiated by Nitric Oxide. Proc. W. Pharmacol. 44:23-4, 2001. (IF:1.739, Q3).
  62. WW Lautt, MP Macedo, P Sadri, S Takayama, F Duarte Ramos and DJ Legare. Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fasting. Am J Physiol Gastrointest Liver Physiol 281(1):G29-36; 2001. (IF: 3.729, Q1).
  63. AM Sebastião, MP Macedo and JA Ribeiro. Tonic activation of A2a adenosine receptors unmasks, and of A1 receptors prevents, a facilitatory action of calcitonin gene-related peptide in the rat hippocampus. B. J. of Pharmacol. 129, 374-380, 2000. (IF: 3.657, Q1).
  64. T Ferreira, MP Macedo, S Ferreira, R Ferreira, P Mata and C. Bárbara. Nitric oxide in expired air as a marker of endothelial activity. Pathophysiology 5(supple1): 68, 1998. (IF: 2.490, Q2).
  65. WW Lautt, X Wang, P Sadri, D Legare and MP Macedo. Further assessment of a new Insulin Sensitivity Test. Can. J. of Physiol. Pharmacol., 76: 1-7, 1998. (IF: 2.210, Q2).
  66. MP Macedo and WW Lautt. Shear induced modulation of vasoconstriction in the hepatic artery and portal vein by nitric oxide. Am. J. Physiology, 274 (Gastrointest. Liver Physiol. 37): G253-G260, 1998. (IF:3.729, Q1).
  67. MP Macedo and WW Lautt. Potentiation to vasodilators by nitric oxide synthase blockade in the superior mesenteric but not hepatic artery. Am J Physiology. 272 (Gastrointest. Liver Physiol. 35): G507-G514, 1997. (IF: 3.729, Q1).
  68. WW Lautt and MP Macedo. Hepatic circulation and toxicology. Drug Metabolism Rev. 29(1&2), 369-395, 1997. (IF: 6.263, Q1).
  69. MP Macedo and W.W. Lautt. Autoregulation capacity in the superior mesenteric artery is attenuated by nitric oxide and adenosine. Am J Physiology 271 (Gastrointest. Liver Physiol. 34): G400-G404, 1996. (IF: 3.729, Q1).
  70. MP Macedo and WW Lautt. Shear induced modulation by inhibition of nitric oxide synthase of sympathetic activity in the superior mesenteric artery. Can. J. Physiol. Pharmacol. 74:692-700, 1996. (IF: 2.210, Q2).
  71. MP Macedo and WW Lautt. Nitric oxide synthase antagonism potentiates pressure-flow autoregulation in the superior mesenteric artery. Proc West Pharmacol Soc 38:33-34, 1995. (IF:1.739, Q3).
  72. MP Macedo and WW Lautt. Nitric oxide suppression of norepinephrine release from nerves in the superior mesenteric artery. Proc West Pharmacol Soc 37:103-104, 1994. (IF:1.739, Q3).