Publications

For detailed information, check Paula Macedo’s Google Scholar
  1. Pinheiro T, Ferrão J, Marques AC, Oliveira MJ, Batra NM, Costa PMFJ, Macedo MP, Águas H, Martins R, Fortunato E. Paper-Based In-Situ Gold Nanoparticle Synthesis for Colorimetric, Non-Enzymatic Glucose Level Determination . Nanomaterials 2020, 10, 2027.
  2. Svegliati-Baroni G, Patrício B, Lioci G, Macedo MP, Gastaldelli A. Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH . Int J Mol Sci. 2020;21(16):5820.
  3. Pina AF, Borges DO, Meneses MJ, Branco P, Birne R, Vilasi A, Macedo MP. Insulin: trigger and target of renal functions. Front Cell Dev Biol. 2020 8:519.
  4. Alemany-Pagès M, Moura-Ramos M, Araújo S, Macedo MP, Ribeiro RT, do Ó D, Ramalho-Santos J, Azul AM. Insights from qualitative research on NAFLD awareness with a cohort of T2DM patients: time to go public with insulin resistance? BMC Public Health 2020 1142(2020).
  5. Sousa-Lima I, Fernandes AB, Patarrão RS, Kim YB, Macedo MP. S-Nitrosoglutathione Reverts Dietary Sucrose-Induced Insulin Resistance. Antioxidants 2020, 9(9):870.
  6. Pina AF, Patarrão RS, Ribeiro RT, Penha-Gonçalves C, Raposo JF, Gardete-Correia L, Duarte R, Boavida JM, Medina JL, Henriques R, Macedo MP. Metabolic Footprint, towards Understanding Type 2 Diabetes beyond Glycemia . J Clin Med 2020, 9(8):2588.
  7. Bergman M, Abdul-Ghani M, DeFronzo RA, Manco M, Sesti G, Fiorentino TV, Ceriello A, Rhee M, Phillips LS, Chung S, Cravalho C, Jagannathan R, Monnier L, Colette C, Owens D, Bianchi C, Del Prato S, Monteiro MP, Neves JS, Medina JL, Macedo MP, Ribeiro RT, Raposo JF, Dorcely B, Ibrahim N, Buysschaert M. Review of methods for detecting glycemic disorders. Diabetes Res Clin Pr 2020, 165:108233.
  8. Bento G, Shafigullina AK, Rizvanov AA, Sardão VA, Macedo MP, Oliveira PJ. Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine . Cells 2020, 9:573.
  9. Pina A, Helgadottir S, Mancina RM, Pavanello C, Pirazzi C, Montalcini T, Henriques R, Calabresi L, Wiklund O, Macedo MP, Valenti L, Volpe G, Romeo S. Virtual genetic diagnosis for familial hypercholesterolemia powered by machine learning. Eur J Prev Cardiol 2020 Oct;27(15):1639-1646.
  10. Silva J, Marques C, Martins F, Viegas I, Tavares L, Macedo MP*, Jones JG*. Determining Contributions of Exogenous Glucose and Fructose to de novo Fatty Acid and Glycerol Synthesis in Liver and Adipose Tissue. Metab Eng 2019, 2019 Dec;56:69-76.
  11. Meneses MJ, Silvestre R, Sousa-Lima I, Macedo MP. Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders. Int J Mol Sci. 2019 Aug 20(16):4049.
  12. Belew GD, Silva J, Rito J, Tavares L, Viegas I, Teixeira J, Oliveira PJ, Macedo MP, Jones JG. Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis. J Lipid Res. 2019 Dec;60(12):2050-2056.
  13. Meneses MJ, Borges DO, Dias TR, Martins FO, Oliveira PF, Macedo MP*, Alves MG*. Knockout of insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality. Mol Cell Endocrinol. 2019 Apr 15;486:11-17.
  14. Matos AM, Martins A, Man T, Evans D, Walter M, Oliveira MC, Lopez-López O, Fernandez-Bolaños JM, Dätwyler P, Ernst B, Macedo MP, Contino M, Colabufo N, Rauter AP. Design and synthesis of CNS-targeted flavones and analogues with neuroprotective potential against H2O2- and Abeta1-42-induced toxicity in SH-SY5Y human neuroblastoma cells. Pharmaceutics. 2019 Jun; 12(2): 98.
  15. Borges DO*, Meneses MJ*, Dias TR, Martins FO, Oliveira PF, Alves MG, Macedo MP. Data on metabolic profile of insulin-degrading enzyme knockout mice . Data in Brief, 2019 May 24;25:104023.
  16. Gonçalves-Dias C, Morello J, Correia MJ, Coelho NR, Antunes AMM, Macedo MP, Monteiro EC, Soto K, Pereira SA. Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease. Nephron. 2019 Jan 9:1-7.
  17. Dias C, Matos AM, Blásquez-Sanchez MT, Calado P, Martins A, Dätwyler P, Ernst B, Macedo MP, Colabufo N, Rauter AP. 2-Deoxyglycosylation towards more effective and bioavailable neuroprotective molecules inspired by nature . Pure Appl Chem.
  18. Huang H, Lee S, Sousa-Lima I, Kim SS, Hwang WM, Dagon Y, Kang M, Seo JA, Shibata M, Cho H, Belew GD, Bhin J, Desai BN, Ryu MJ, Shong M, Li P, Meng H, Chung B, Hwang D, Kim M, Park KS, Macedo MP, White M, Jones J, Kim YB. Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition. J Clin Invest. 2018 Dec 3;128(12):5335-5350.
  19. Duarte N, Coelho I, Holovanchuk D, Almeida JI, Penha-Gonçalves C and Macedo MP. Dipeptidyl Peptidase-4 (CD26/DPP-4) is a Pro-recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells. Hepatology Communications. 2018 Sep 7;2(9):1080-1094. doi: 10.1002/hep4.1225. eCollection.
  20. de Matos AM, Macedo MP, Rauter A. Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential. Med Res Rev. 2017-04-19. (IF: 8.290, Q1).
  21. Sousa-Lima I, Park S, Chung M, Macedo MP, Kim YB. Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice. Metabolism. October 2016. 65(10):1508–1521.
  22. Martins M, Boavida JM, Raposo JF, Froes F, Nunes B, Ribeiro RT, Macedo MP, Penha-Gonçalves C. Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients. BMJ Open Diabetes Res Care ;4(1):e000181.
  23. Coelho M, Mendes VM, Lima IS, Martins FO, Fernandes AB, Macedo MP, Jones JG, Manadas B. Direct analysis of [6,6-(2)H2]glucose and [U-(13)C6]glucose dry blood spot enrichments by LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:242-8.
  24. Gaspar JM, Baptista FI, Macedo MP, Ambrósio AF. Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline. ACS Chem Neurosci. 2016 Feb 17;7(2):131-42.
  25. Martins FO, Delgado TC, Viegas J, Gaspar JM, Scott DK, O'Doherty RM, Macedo MP*, Jones JG*. Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia. Br J Pharmacol. 2016 Jan;173(2):267-78.
  26. Tricò D, Baldi S, Tulipani A, Frascerra S, Macedo MP, Mari A, Ferrannini E, Natali A. Mechanisms through which a small protein and lipid preload improves glucose tolerance in subjects with normal or impaired glucose homeostasis . Diabetologia. 2015 Nov;58(11):2503-12.
  27. Afonso R, Gaspar J, Lamarão I, Lautt WW, Macedo MP. Postprandial insulin action relies on meal composition and hepatic parasympathetics: dependency on glucose and amino acids. J Nutr Biochem. 2016 Jan; 27:70-8.
  28. Duarte N, Coelho I, Patarrão R, Almeida J, Penha-Gonçalves C and Macedo MP. How inflammation impinges on NAFLD: a role for Kupffer cells. Biomed Res Int. 2015:984578.
  29. Patarrão RS, Lautt WW, Macedo MP. Acute glucagon induces postprandial peripheral insulin resistance. PLoS One. 2015;10(5):e0127221.
  30. Jesus AR, Dias C, Matos AM, de Almeida RF, Viana AS, Marcelo F, Ribeiro RT, Macedo MP, Airoldi C, Nicotra F, Martins A, Cabrita EJ, Jiménez-Barbero J, Rauter AP. Exploiting the therapeutic potential of 8-β-d-glucopyranosylgenistein: synthesis, antidiabetic activity, and molecular interaction with islet amyloid polypeptide and amyloid β-peptide (1-42). 2014. J Med Chem. Nov 26;57(22):9463-72.
  31. Macedo MP*. Bridges in translational medicine: a case for metabolism, inflammation, and nutrition. 2014. C. J Physiol Pharmacol. Aug;92(8):iii.
  32. Macedo MP*, Lima IS, Gaspar JM, Afonso RA, Patarrão RS, Kim YB, Ribeiro RT. Risk of postprandial insulin resistance: the liver/vagus rapport. 2014. Rev Endocr Metab Disord. Mar;15(1):67-77.
  33. Trovoada M de J, Martins M, Ben Mansour R, Sambo Mdo R, Fernandes AB, Antunes Gonçalves L, Borja A, Moya R, Almeida P, Costa J, Marques I, Macedo MP, Coutinho A, Narum DL, Penha-Gonçalves C. NOS2 variants reveal a dual genetic control of nitric oxide levels, susceptibility to Plasmodium infection, and cerebral malaria. 2014. Infect Immun. Mar;82(3):1287-95.
  34. Pinto P, Bárbara C, Montserrat JM, Patarrão RS, Guarino MP, Carmo MM, Macedo MP, Martinho C, Dias R, Gomes MJ. Effects of CPAP on nitrate and norepinephrine levels in severe and mild-moderate sleep apnea. 2013. BMC Pulm Med. Mar 13;13:13.
  35. Delgado TC, Martins F, Carvalho F, Gonçalves A, Scott DK, O’Doherty R, Macedo MP and Jones JG. 2H-enrichment distribution of hepatic glycogen from 2H2O reveals the contribution of dietary fructose to glycogen synthesis. 2013. Am J Physiol. 304: E000–E000.
  36. Martins FO, Rito J, Jarak I, Viegas I, Pardal MA, Macedo MP, Jones JG. Disposition of [U-2H7]glucose into hepatic glycogen in rat and in seabass. 2013. Comp Biochem Physiol A Mol Integr Physiol. Oct;166(2):316-22.
  37. Natali A, Ribeiro R, Baldi S, Tulipani A, Rossi M, Venturi E, Mari A, Macedo MP, Ferrannini E. Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion. 2013. Diabetologia. May;56(5):1183-91.
  38. Afonso RA, Fernandes AB, Santos C, Ligeiro D, Ribeiro RT, Patarrão RS, Lima IS, Videira PA, Caldeira J, Macedo MP. Postprandial insulin resistance in zucker diabetic fatty rats is associated with parasympathetic-no axis deficiencies. 2012. J. Neuroendocrinol. Oct;24(10):1346-55.
  39. Patarrão RS, Lautt WW, Afonso RA, Ribeiro RT, Fernandes AB, Boavida JM, Macedo MP. Postprandial but not fasting insulin resistance is an early identifier of dysmetabolism in overweight subjects. 2012. Can. J Physiol Pharmacol. 90(7):923-31.
  40. Fernandes AB, Guarino MP, Macedo MP. Understanding the in-vivo relevance of S-nitrosothiols in insulin action . 2012. Can J Physiol Pharmacol. Jul;90(7):887-9.
  41. Lautt WW, Schafer J, Macedo MP and Legare DJ. Bethanechol and N-acetylcysteine mimic feeding signals and reverse insulin resistance in fasted and sucrose-induced diabetic rats. Can J Physiol Pharmacol. 89, 135-142, 2011.
  42. Fernandes AB, Patarrão RS, Videira PA and Macedo MP. Understanding postprandial glucose clearance by peripheral tissues: the role of the hepatic parasympathetic system. 2011. J Neuroendocrinol. Dec;23(12):1288-95.
  43. Afonso RA, Lautt WW, Schafer J, Legare DJ, Oliveira AG and Macedo MP. High-fat diet results in post-prandial insulin resistance that involves parasympathetic dysfunction. Br J Nutr. Nov; 104(10): 1450-9, 2010.
  44. Lautt WW, Ming Z, Macedo MP, Legare DJ. HISS-dependent insulin resistance (HDIR) in aged rats is associated with adiposity, progresses to syndrome X, and is attenuated by a unique antioxidant cocktail. Exp Gerontol. Aug;43(8):790-800, 2008.
  45. Ribeiro RT, Afonso RA, Guarino MP, Macedo MP. Loss of Postprandial Insulin Sensitization During Aging . J Gerontol A Biol Sci Med Sci. 63: 560-565, 2008.
  46. Patarrão RS, Lautt WW, Guarino MP, Afonso RA, Ribeiro RT, Fernandes AB, Boavida JM and Macedo MP. Meal-induced insulin sensitization and its parasympathetic regulation in humans. Can J Physiol Pharmacol. 86:880-888. 2008.
  47. Afonso RA, Lautt WW, Ribeiro RT, Legare D, Macedo MP. Insulin resistance in two animal models of obesity: a comparison between the high-fat diet-fed and the Zucker rats . Proc West Pharmacol Soc 50: 110-114, 2007.
  48. Afonso RA, Ribeiro RT, Fernandes AB, Patarrão RS, Macedo MP. Hepatic-dependent and -independent insulin actions are impaired in the obese Zucker rat model. Obesity, Silver Spring.15(2):314-21, 2007.
  49. Ribeiro RT, Afonso RA and Macedo MP. Hepatic parasympathetic role in insulin resistance on an animal model of hypertension. Metabolism 56: 227-233, 2007.
  50. Patarrão RS, Lautt WW, Guarino M, Afonso RA, Ribeiro RT, Fernandes AB, Boavida JM and Macedo MP. A New Technique to Assess Insulin Sensitivity in Humans: The Rapid Insulin Sensitivity Test (RIST). Proc West Pharmacol Soc. 50: 105-109, 2007.
  51. Santos C, Afonso RA, Guarino MP, Patarrão RS, Fernandes AB, Macedo MP, Caldeira J. In vitro Nitrosation of insulin A and B-chains . EJMS 12: 331-338, 2006.
  52. Guarino MP, and Macedo MP. Coadministration of glutathione and nitric oxide enhances insulin sensitivity in wistar rats. Br J Pharmacol 147(8):959-965, 2006.
  53. Sadri P, Reid MAG, Afonso RA, Macedo MP, Schafer J, Legare DJ, Lautt WW. Meal-induced insulin sensitization quantified in conscious and anesthetized rat models comparing liquid mixed meal with glucose and sucrose . Br J Nutr. 95: 288-295, 2006.
  54. Afonso RA, Patarrão RS, Macedo MP, Carmo MM. Carvedilol Action is Dependent on Endogenous Production of Nitric Oxide. Am J of Hypertension April 19:419-425; 2006.
  55. Ribeiro RT, Lautt WW, Legare DJ and Macedo MP. Insulin resistance induced by sucrose-feeding is due to an impairment of the Hepatic Parasympathetic Nerves. Diabetologia 48: 976-983; 2005.
  56. Lautt WW, Macedo MP, Sadri P, Legare DJ, Reid MA, Guarino MP. Pharmaceutical reversal of insulin resistance. Proc West Pharmacol Soc. 47: 30-32, 2004.
  57. Guarino MP, Correia NC, Lautt WW, Macedo MP. Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver. Am J Physiol Gastrointest Liver Physiol. 287: G527-G532, 2004.
  58. Afonso RA, Ribeiro RT and Macedo MP. Defective hepatic nitric oxide action results in HISS-dependent insulin resistance in spontaneously hypertensive rats. Proc West Pharmacol Soc. 47, 2004.
  59. Guarino MP, Afonso RA, Raimundo N, Raposo JF, Macedo MP. Hepatic gluthatione and nitric oxide are critical for hepatic insulin-sensitizing substance action . Am J Physiol Gastrointest Liver Physiol Jul; 284(4):G588-594, 2003.
  60. Correia NC, Guarino MP, Raposo J, Macedo MP. Hepatic guanylyl cyclase inhibition induces HISS-dependent insulin resistance. Proc West Pharmacol Soc. 45:57-58, 2002.
  61. Ribeiro RT, Afonso RA and Macedo MP. The action of hepatic insulin sensitizing substance: gender comparison in wistar rats. Proc West Pharmacol Soc. 45:55-56, 2002.
  62. Ribeiro RT, Duarte-Ramos F and Macedo MP. The action of hepatic insulin sensitizing substance is decreased in rats on a high-sucrose diet . Proc West Pharmacol Soc. 44: 31-32, 2001.
  63. Ribeiro RT, Duarte-Ramos F and Macedo MP. The fatty zucker rat fa/fa shows a dysfunction of the HISS-dependent and - independent components of insulin action. Proc West Pharmacol Soc. 44:29-30, 2001.
  64. Ribeiro RT, Duarte-Ramos F and Macedo MP. Effect of the hepatic insulin sensitizing substance (HISS) action in the spontaneously hypertensive rats. Proc West Pharmacol Soc. 44:27-28, 2001.
  65. Guarino MP, Correia NC, Raposo JF and Macedo MP. Nitric oxide synthase inhibition decreases hepatic insulin sensitizing substance output which is reversed by SIN-1 but not by nitroprusside. Proc West Pharmacol Soc. 44:25-6, 2001.
  66. Patarrão R, Macedo MP, Carmo MM. Hepatic Metabolic Effects of Norepinephrine are potentiated by Nitric Oxide. Proc West Pharmacol Soc. 44:23-4, 2001.
  67. Lautt WW, Macedo MP, Sadri P, Takayama S, Ramos FD and Legare DJ. Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fasting. Am J Physiol Gastrointest Liver Physiol 281(1):G29-36; 2001.
  68. Sebastião AM, Macedo MP and Ribeiro JA. Tonic activation of A2a adenosine receptors unmasks, and of A1 receptors prevents, a facilitatory action of calcitonin gene-related peptide in the rat hippocampus. B J of Pharmacol. 129, 374-380, 2000.
  69. Ferreira T, Macedo MP, Ferreira S, Ferreira R, Mata P and Bárbara C. Nitric oxide in expired air as a marker of endothelial activity. Pathophysiology 5(supple1): 68, 1998.
  70. Lautt WW, Wang X, Sadri P, Legare DJ, Macedo MP. Rapid insulin sensitivity test (RIST). Can J of Physiol Pharmacol., 76: 1-7, 1998.
  71. Macedo MP and Lautt WW. Shear induced modulation of vasoconstriction in the hepatic artery and portal vein by nitric oxide . Am J Physiology, 274 (Gastrointest. Liver Physiol. 37): G253-G260, 1998.
  72. MP Macedo and WW Lautt. Potentiation to vasodilators by nitric oxide synthase blockade in the superior mesenteric but not hepatic artery. Am J Physiology. 272 (Gastrointest. Liver Physiol. 35): G507-G514, 1997.
  73. WW Lautt and MP Macedo. Hepatic circulation and toxicology. Drug Metabolism Rev. 29(1&2), 369-395, 1997.
  74. MP Macedo and WW Lautt. Autoregulation capacity in the superior mesenteric artery is attenuated by nitric oxide and adenosine. Am J Physiology 271 (Gastrointest. Liver Physiol. 34): G400-G404, 1996.
  75. MP Macedo and WW Lautt. Shear induced modulation by inhibition of nitric oxide synthase of sympathetic activity in the superior mesenteric artery. Can J Physiol Pharmacol. 74:692-700, 1996. (IF: 2.210, Q2).
  76. MP Macedo and WW Lautt. Nitric oxide synthase antagonism potentiates pressure-flow autoregulation in the superior mesenteric artery. Proc West Pharmacol Soc 38:33-34, 1995.
  77. MP Macedo and WW Lautt. Nitric oxide suppression of norepinephrine release from nerves in the superior mesenteric artery. Proc West Pharmacol Soc 37:103-104, 1994.