Medir

MAIN INTERESTS

Prediabetes and Diabetes and Comorbidities

Our major interest is to understand the pathophysiology of Pre-Diabetes and Type 2 Diabetes (T2D) and comorbidities and to effectively translate that knowledge into the diagnosis and treatment of these multi-systemic disorders. Therefore, we use an integrative approach looking at classical target tissues for insulin action: liver, muscle and fat, as well as, at other targets such as the brain. In a truly translational approach we use a wide range of genetic, using genetically engineered mice, and biochemical approaches both in vitro, in vivo, ex vivo and in human subjects. These studies are expected to lead to the development of novel biomarkers and therapeutic interventions in T2D and to the improvement of health and wellbeing

Photo of Me

To dissect the dynamics of Pre-Diabetes and Type 2 Diabetes and comorbidities, our lab is currently conducting the following related and highly-integrated projects.

Research

Research Areas

Hepatic Insulin Clearance
From Genetics To Patient Clustering
Gut-Liver Axis
NAFDL

From Genetics To Patient Clustering

Gut-Liver Axis

Hepatic Insulin Clearance

NAFDL: Non-alcoholic fatty liver diseas

Brain-Liver Axis
Insulin

Brain-Liver Axis

Insulin Receptor Trafficking

CONTACT

WHERE WE WORK

CEDOC - Centro De Estudos De Doenças Crónicas
Rua Camara Pestana, nº 6A, Lab 3.8
1150-082 Lisboa, Portugal
(+351) 218 803 101 (Ext 26011)
Email: paula.macedo@nms.unl.pt
APDP - Associação Protectora dos Diabéticos de Portugal
Rua Rodrigo da Fonseca, nº 1
1250-189 Lisboa, Portugal
(+351) 213 816 100
Email: diabetes@apdp.pt
Universidade de Aveiro
Departamento de Ciências Médicas
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Email: paula.macedo@ua.pt